I’m guessing—and this is only a guess—that this is one of the earlier Mail Pouch Tobacco signs. When the Bloch Brothers Tobacco Company started making chewing tobacco in the late nineteenth century, they advertised primarily on the sides of buildings. It was only later they became famous for their advertisements on the sides of barns.
This one, on the corner of Leonard and E Main in Beacon, NY, is also distinctive because it doesn’t contain the standard Mail Pouch slogan: “Treat Yourself to the Best”. Instead, in the lower left it says
This is the first time I’ve seen smoking tobacco advertised on the same sign as Mail Pouch Chewing Tobacco. There’s a first time for everything.